Aquaporin 2 (AQP2) Rabbit Polyclonal Antibody

CAT#: TA326697

Rabbit Polyclonal AQP2 Antibody

Product Images

Western blot analysis of AQP2 in A431 cell lysate with AQP2 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of AQP2 in human kidney tissue with AQP2 antibody at 5 ug/mL.

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  Immunofluorescence of AQP2 in human kidney tissue with AQP2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: AQP2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AQP2.
• Formulation: AQP2 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: AQP2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 30 kDa; Observed: 28 kDa
• Gene Name: aquaporin 2
• Database Link:
  NP_000477
  Entrez Gene 11827 MouseEntrez Gene 25386 RatEntrez Gene 359 Human
  UniProt ID P41181
• Background: Aquaporins are membrane proteins that serve in the transfer of water and small solutes across cellular membranes. One such aquaporin, aquaporin-2 (AQP2) is located in the kidney collecting tubule and plays a critical role in water reabsorbtion (1). AQP2 is mainly localized in intracellular vesicles but upon stimulation with anti-diuretic hormone (ADH), AQP2 is translocated to the apical plasma membrane by exocytic fusion of AQP2-bearing vesicles (2). Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus (3).
• Synonyms: AQP-CD; WCH-CD

Reference Data

• Protein Families: Druggable Genome, Transmembrane