CCR7 Rabbit Polyclonal Antibody

CAT#: TA326705

Rabbit Polyclonal CCR7 Antibody

Product Images

Western blot analysis of CCR7 in human spleen tissue lysate with CCR7 antibody at 1 ug/ml.

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  Immunohistochemistry of CCR7 in human spleen tissue with CCR7 antibody at 5 ug/mL.

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  Immunofluorescence of CCR7 in human spleen tissue with CCR7 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CCR7 antibody was raised against a 15 amino acid peptide near the center of human CCR7.
• Formulation: CCR7 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CCR7 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 42 kDa; Observed: 42 kDa
• Gene Name: C-C motif chemokine receptor 7
• Database Link:
  NP_001829
  Entrez Gene 1236 Human
  UniProt ID P32248
• Background: The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2). The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3).
• Synonyms: BLR2; CD197; CDw197; CMKBR7; EBI1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction