TRPV4 Rabbit Polyclonal Antibody

CAT#: TA326707

Rabbit Polyclonal TRPV4 Antibody

Product Images

Western blot analysis of TRPV4 in (A) human testis tissue and (B) SK-N-SH cell lysate with TRPV4 antibody at 1ug/ml.

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  Immunohistochemistry of TRPV4 in human kidney tissue with TRPV4 antibody at 2ug/ml.

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  Immunohistochemistry of TRPV4 in human lung tissue with TRPV4 antibody at 5ug/ml.

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  Immunofluorescence of TRPV4 in human lung tissue with TRPV4 antibody at 20ug/ml.

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  Immunofluorescence of TRPV4 in human kidney tissue with TRPV4 antibody at 5ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.
• Formulation: TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TRPV4 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 96 kDa; Observed: 110 kDa
• Gene Name: transient receptor potential cation channel subfamily V member 4
• Database Link:
  NP_067638
  Entrez Gene 59341 Human
  UniProt ID Q9HBA0
• Background: The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).
• Synonyms: BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; VRL2; VROAC

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane