UCP1 Rabbit Polyclonal Antibody

CAT#: TA326708

Rabbit Polyclonal UCP1 Antibody

Product Images

Western blot analysis of UCP1 in HeLa cell lysate with UCP1 antibody at 1 ug/ml.

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  Immunohistochemistry of UCP1 in human liver tissue with UCP1 antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: UCP1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human UCP1 (GenBank accession.
• Formulation: UCP1 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: UCP1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 34 kDa; Observed: 36 kDa
• Gene Name: uncoupling protein 1
• Database Link:
  NP_068605
  Entrez Gene 22227 MouseEntrez Gene 24860 RatEntrez Gene 7350 Human
  UniProt ID P25874
• Background: The mitochondrial brown fat uncoupling protein 1 (UCP1) is a member of the family of mitochondrial anion carrier proteins (MACP) (1). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells (1). UCP1 is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat (1).
• Synonyms: SLC25A7; UCP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease, PPAR signaling pathway