SUZ12 Rabbit Polyclonal Antibody

CAT#: TA326710

Rabbit Polyclonal SUZ12 Antibody

Product Images

Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 ug/ml.

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  Immunohistochemistry of SUZ12 in human lung tissue with SUZ12 antibody at 5 ug/mL.

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  Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12.
• Formulation: SUZ12 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SUZ12 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 81 kDa; Observed: 96 kDa
• Gene Name: SUZ12 polycomb repressive complex 2 subunit
• Database Link:
  NP_056170
  Entrez Gene 23512 Human
  UniProt ID Q15022
• Background: The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3,4). SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5).
• Synonyms: CHET9; JJAZ1

Reference Data

• Protein Families: Transcription Factors