FMRP (FMR1) Rabbit Polyclonal Antibody

CAT#: TA326712

Rabbit Polyclonal FMR1 Antibody

Product Images

Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 ug/ml.

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  Immunohistochemistry of FMR1 in human brain tissue with FMR1 antibody at 2.5 ug/mL.

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  Immunofluorescence of FMR1 in human brain tissue with FMR1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1.
• Formulation: FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: FMR1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 70 kDa; Observed: 74 kDa
• Gene Name: fragile X mental retardation 1
• Database Link:
  NP_002015
  Entrez Gene 14265 MouseEntrez Gene 24948 RatEntrez Gene 2332 Human
  UniProt ID Q06787
• Background: Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
• Synonyms: FMRP; FRAXA; POF; POF1; POFX

Reference Data

• Protein Families: Druggable Genome