alpha 1 Fetoprotein (AFP) Rabbit Polyclonal Antibody

CAT#: TA326765

Rabbit anti-AFP Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cells, using AFP antibody.

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  Western blot analysis of extracts of A549 cells, using AFP antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Mouse, Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: C term -peptide of human AFP
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 65 kDa
• Gene Name: alpha fetoprotein
• Database Link:
  NP_001125
  Entrez Gene 11576 MouseEntrez Gene 24177 RatEntrez Gene 174 Human
  UniProt ID P02771
• Background: Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the serum of the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells. The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Elevated serum levels are predictive of hepatocellular carcinoma.
• Synonyms: AFPD; FETA; HPAFP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein