Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

CAT#: TA326769

APP Rabbit Polyclonal Antibody


USD 275.00

3 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1:500-1:2000;IHC: 1:50-1:200
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen N term -peptide of human APP
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name amyloid beta precursor protein
Background Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDatransmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Aβ), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M-phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).1. Selkoe, D.J. (1996) J Biol Chem 271, 18295-8.2. Caporaso, G.L. et al. (1992) Proc Natl Acad Sci USA 89, 3055-9.3. Hung, A.Y. and Selkoe, D.J. (1994) EMBO J 13, 534-42.4. Suzuki, T. et al. (1994) EMBO J 13, 1114-22.5. Ando, K. et al. (1999) J Neurosci 19, 4421-7.6. Iijima, K. et al. (2000) J Neurochem 75, 1085-91.
Synonyms AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.