IKBKE Rabbit Polyclonal Antibody

CAT#: TA326793

IKBKE Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using IKBKE antibody.

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  Immunohistochemistry of human pancreatic tissue using IKBKE Antibody

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  Immunohistochemistry of paraffin-embedded mouse lung using IKBKE antibody at dilution of 1:100 (400x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human IKBKE
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
• Database Link:
  NP_054721
  Entrez Gene 56489 MouseEntrez Gene 363984 RatEntrez Gene 9641 Human
  UniProt ID Q14164
• Background: IKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. It has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. IKK epsilon phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It plays a special role in the immune response. IKK epsilon protects cells against DNA damage-induced cell death.
• Synonyms: IKK-E; IKK-i; IKKE; IKKI

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway