Lamin A (LMNA) Rabbit Polyclonal Antibody

CAT#: TA326797

LMNA Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using LMNA antibody.

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  Immunohistochemical staining of paraffin-embedded human breast tumor, showing staining of the nuclear envelope, using LMNA Antibody.

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  Immunofluorescence analysis of HeLa cell using LMNA antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ChIP, ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human LMNA
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lamin A/C
• Database Link:
  NP_005563
  Entrez Gene 16905 MouseEntrez Gene 60374 RatEntrez Gene 4000 Human
  UniProt ID P02545
• Background: Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.
• Synonyms: CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)