Midkine (MDK) Rabbit Polyclonal Antibody

CAT#: TA326798

MDK Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of SW480 cells, using MDK antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human MDK
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: midkine (neurite growth-promoting factor 2)
• Database Link:
  NP_002382
  Entrez Gene 17242 MouseEntrez Gene 81517 RatEntrez Gene 4192 Human
  UniProt ID P21741
• Background: Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecule¡¯s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule¡¯s neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA).
• Synonyms: ARAP; MK; NEGF2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane