PSME3 Rabbit Polyclonal Antibody

CAT#: TA326811

PSME3 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PSME3 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PSME3
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30 kDa
• Gene Name: proteasome activator subunit 3
• Database Link:
  NP_005780
  Entrez Gene 287716 RatEntrez Gene 10197 Human
  UniProt ID P61289
• Background: The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. There are three evolutionarily conserved subunits of PA28: PA28a (PSME1), PA28β (PSME2), and PA28? (PSME3) . PA28a and PA28β form a heteroheptameric complex and function by binding to the 20S complex at its opening site(s). The PA28a/β complex is present throughout the cell and participates in MHC class I antigen presentation by promoting the generation of antigenic peptides from foreign proteins. PA28? exists in the form of a homoheptamer and is mainly located in the nucleus. The PA28? complex exerts its function by binding and guiding specific nuclear target proteins to the 20S proteasome for further degradation.
• Synonyms: HEL-S-283; Ki; PA28-gamma; PA28G; PA28gamma; REG-GAMMA

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: Antigen processing and presentation, Proteasome