Grp75 (HSPA9) Rabbit Polyclonal Antibody

CAT#: TA326841

Rabbit anti-HSPA9 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HSPA9 antibody.

• 

  Immunohistochemistry of paraffin-embedded rat kidney using HSPA9 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded human esophageal cancer using HSPA9 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded mouse lung using HSPA9 antibody at dilution of 1:200 (400x lens).

• 

  Immunofluorescence analysis of U2OS cell using HSPA9 antibody. Blue: DAPI for nuclear staining.

Show all 5 images

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HSPA9
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 74 kDa
• Gene Name: heat shock protein family A (Hsp70) member 9
• Database Link:
  NP_004125
  Entrez Gene 15526 MouseEntrez Gene 291671 RatEntrez Gene 3313 Human
  UniProt ID P38646
• Background: Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat-inducible. This protein is essential for transporting many mitochondrial proteins from the cytoplasm to mitochondria. Grp75 inactivates the tumor suppressor p53. Studies found that Grp75 is overexpressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts.
• Synonyms: CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: RNA degradation