VDAC1 Rabbit Polyclonal Antibody

CAT#: TA326858

VDAC1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using VDAC1 antibody.

• 

  Immunohistochemistry of paraffin-embedded human stomach cancer using VDAC1 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human VDAC1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: voltage dependent anion channel 1
• Database Link:
  NP_003365
  Entrez Gene 22333 MouseEntrez Gene 83529 RatEntrez Gene 7416 Human
  UniProt ID P21796
• Background: Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics. Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c. In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3.
• Synonyms: PORIN; VDAC-1

Reference Data

• Protein Families: Ion Channels: Other
• Protein Pathways: Calcium signaling pathway, Huntington's disease, Parkinson's disease