Parkin (PARK2) Rabbit Polyclonal Antibody

CAT#: TA326867

PARK2 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of PC12 cell and brain cell lysate using PARK2 antibody.

Specifications

Product Data

• Applications: ELISA, ICC/IF, IHC, WB
• Recommended Dilution: WB,1:500 - 1:1000
  IHC-P,1:50 - 1:200
  IF/ICC,1:50 - 1:200
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52kDa
• Gene Name: parkin RBR E3 ubiquitin protein ligase
• Database Link:
  NP_054642
  Entrez Gene 50873 MouseEntrez Gene 56816 RatEntrez Gene 5071 Human
  UniProt ID O60260
• Background: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
• Synonyms: AR-JP; LPRS2; PDJ; PRKN

Reference Data

• Protein Pathways: Parkinson's disease, Ubiquitin mediated proteolysis