MSH6 Rabbit Polyclonal Antibody

CAT#: TA326879

MSH6 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using MSH6 antibody.

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  Immunohistochemistry of paraffin-embedded rat testis using MSH6 antibody at dilution of 1:100 (200x lens).

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  Immunofluorescence analysis of HeLa cell using MSH6 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:20- 1:100
• Reactivities: Human, Mouse, Rat, Monkey
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human MSH6
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mutS homolog 6
• Database Link:
  NP_000170
  Entrez Gene 17688 MouseEntrez Gene 100360342 RatEntrez Gene 2956 Human
  UniProt ID P52701
• Background: The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-a dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-a is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance
• Synonyms: GTBP; GTMBP; HNPCC5; HSAP; p160

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Colorectal cancer, Mismatch repair, Pathways in cancer