PARK7 Rabbit Polyclonal Antibody

CAT#: TA326883

Rabbit anti-PARK7 Polyclonal Antibody

Product Images

Western blot analysis of Jurkat cell lysate using PAPK7 antibody.

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  Immunofluorescence analysis of HeLa cell using PARK7 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PARK7
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Parkinsonism associated deglycase
• Database Link:
  NP_009193
  Entrez Gene 57320 MouseEntrez Gene 11315 Human
  UniProt ID Q99497
• Background: Parkinsons disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in a-synuclein, Parkin, and DJ-1 are linked to PD. a-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD. Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator of oxidative stress. Dopamine D2 receptor-mediated functions are greatly impaired in DJ-1 (-/-) mice, resulting in reduced long-term depression.
• Synonyms: DJ-1; DJ1; HEL-S-67p

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease