Cyclophilin A (PPIA) Rabbit Polyclonal Antibody

CAT#: TA326885

PPIA Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PPIA antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PPIA
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: peptidylprolyl isomerase A
• Database Link:
  NP_066953
  Entrez Gene 25518 RatEntrez Gene 268373 MouseEntrez Gene 5478 Human
  UniProt ID P62937
• Background: Cyclophilins are a highly conserved family of peptidylprolylcis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines. As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection There is also some evidence that cyclophilins have nuclease activity and play a role in apoptosis.
• Synonyms: CYPA; CYPH; HEL-S-69p