SGK1 Rabbit Polyclonal Antibody

CAT#: TA326894

SGK1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using SGK1 antibody.

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  Immunohistochemistry of paraffin-embedded human stomach using SGK1 antibody at dilution of 1:100 (400x lens).

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  Immunofluorescence analysis of MCF7 cell using SGK1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human SGK1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: serum/glucocorticoid regulated kinase 1
• Database Link:
  NP_005618
  Entrez Gene 20393 MouseEntrez Gene 29517 RatEntrez Gene 6446 Human
  UniProt ID O00141
• Background: Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt (1). SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation.The MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78.
• Synonyms: SGK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase