MAGED1 Rabbit Polyclonal Antibody

CAT#: TA326921

MAGED1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of A549 cell lysate using MAGED1 antibody.

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  Immunohistochemistry of paraffin-embedded liver cancer using MAGED1 antibody at dilution of 1:100 (x400 lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human MAGED1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 86 kDa
• Gene Name: MAGE family member D1
• Database Link:
  NP_008917
  Entrez Gene 84469 RatEntrez Gene 94275 MouseEntrez Gene 9500 Human
  UniProt ID Q9Y5V3
• Background: MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msx homeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptional activation of the p65 subunit of NF-kappaB, via the XIAP-Tak1-Tab1 complex. (20100315, 19639218, 17453828, 15272023) G.
• Synonyms: DLXIN-1; NRAGE

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Neurotrophin signaling pathway