Thymidine Phosphorylase (TYMP) Rabbit Polyclonal Antibody

CAT#: TA326922

TYMP Rabbit Polyclonal Antibody


USD 275.00

3 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution WB 1:500 - 1:2000
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human TYMP
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name thymidine phosphorylase
Background Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function. Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis. Alternatively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment. The use of thymidine phosphorylase as a cancer therapeutic target has been studied extensively, with emphasis on either inhibiting TP enzymatic activity or increasing enzyme induction with concomitant DFUR treatment.
Synonyms ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP
Reference Data
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.