Nicastrin (NCSTN) Rabbit Polyclonal Antibody

CAT#: TA326927

NCSTN Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using NCSTN antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human NCSTN
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 77 kDa
• Gene Name: nicastrin
• Database Link:
  NP_056146
  Entrez Gene 59287 MouseEntrez Gene 289231 RatEntrez Gene 23385 Human
  UniProt ID Q92542
• Background: Nicastrin is a transmembrane glycoprotein serving as an essential component of the ?-secretase complex. Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound ?-secretase complex. Nicastrin also serves as a docking site for ?-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to ?-secretase to ensure the correct cleavage process).
• Synonyms: ATAG1874

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease, Notch signaling pathway