Annexin A1 (ANXA1) Rabbit Polyclonal Antibody

CAT#: TA326936

ANXA1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of Hela cell and NIH3T3 cell lysate using ANXA1 antibody.

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  Immunohistochemistry of paraffin-embedded human endometrial cancer using ANXA1 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human thyroid cancer using ANXA1 antibody at dilution of 1:200 (200x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ANXA1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: annexin A1
• Database Link:
  NP_000691
  Entrez Gene 16952 MouseEntrez Gene 25380 RatEntrez Gene 301 Human
  UniProt ID P04083
• Background: The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology . Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis . Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity . Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis and may be required for a late stage in inward vesiculation . Phosphorylation by PKC, EGFR, and Chak1 results in inhibition of annexin A1 function . Annexin A1 has also been identified as one of the eat-me signals on apoptotic cells that are to be recognized and ingested by phagocytes . Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development .
• Synonyms: ANX1; LPC1

Reference Data

• Protein Families: Druggable Genome