Emerin (EMD) Rabbit Polyclonal Antibody

CAT#: TA326940

Rabbit anti-EMD Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using EMD antibody.

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  Immunohistochemistry of paraffin-embedded human thyroid cancer using EMD antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of HeLa cell using EMD antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:20- 1:100
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human EMD
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: emerin
• Database Link:
  NP_000108
  Entrez Gene 13726 MouseEntrez Gene 2010 Human
  UniProt ID P50402
• Background: Emerin is a broadly expressed integral protein of the nuclear inner membrane . It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions. Emerin may regulate gene expression through binding to other transcriptional regulators. Emerin binds to β-catenin and inhibits its nuclear accumulation. Recent studies demonstrate that Emerin is required for HIV-1 infectivity. Mutations in Emerin are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening.
• Synonyms: EDMD; LEMD5; STA

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)