hnRNP A2B1 (HNRNPA2B1) Rabbit Polyclonal Antibody

CAT#: TA326961

HNRNPA2B1 Rabbit Polyclonal Antibody


USD 374.00

2 Weeks*

Size
    • 100 ul

Product Images

Frequently bought together (2)
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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommended Dilution WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human HNRNPA2B1
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name heterogeneous nuclear ribonucleoprotein A2/B1
Background Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . Alternative splicing produces transcripts that encode two homologous hnRNP proteins, hnRNPA2 and hnRNPB1, from a single gene sequence . Studies demonstrate hnRNP A2/B1 splicing repression across multiple targets and that both proteins can bind and protect telomere repeat sequences from DNase digestion . Altered expression of hnRNP B1 is seen in several forms of cancer, including squamous cell carcinoma, adenocarcinoma, and various forms of lung cancer . Over expression of hnRNP B1 may be associated with inhibition of DNA-PK activity and impaired DNA repair during early stages of cancer development . Autoantigens to hnRNP A2/B1 (termed RA33) are associated with rheumatoid arthritis, systemic lupus erythromatosus and mixed connective tissue disease.
Synonyms HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1
Reference Data
Protein Families Druggable Genome

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