Rab5 (RAB5A) Rabbit Polyclonal Antibody

CAT#: TA326977

Rabbit anti-RAB5A Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using RAB5A antibody.

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  Immunofluorescence analysis of HeLa cell using RAB5A antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human RAB5A
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RAB5A, member RAS oncogene family
• Database Link:
  NP_004153
  Entrez Gene 64633 RatEntrez Gene 271457 MouseEntrez Gene 5868 Human
  UniProt ID P20339
• Background: Rab5 is a member of the Ras superfamily of small Rab GTPases. Rab5 is localized at the plasma membrane and early endosomes and functions as a key regulator of vesicular trafficking during early endocytosis. The conformational change between Rab5 GTP/GDP states is essential for its biological function as a rate limiting regulator at multiple steps during endocytosis. Rab5 exerts its function by interacting with several Rab5-specific effectors. These proteins form complexes with Rab5 on a specialized Rab domain of the endosome and promote recycling of Rab5-cargo targets between endosome and the plasma membrane.
• Synonyms: RAB5

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Endocytosis