PDGF beta (PDGFB) Rabbit Polyclonal Antibody

CAT#: TA326987

Rabbit anti-PDGFB Polyclonal Antibody


USD 275.00

2 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommended Dilution WB 1:500 - 1:2000;IHC 1:50- 1:200
Reactivities Human, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human PDGFB
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name platelet derived growth factor subunit B
Background PDGF-BB is a cystine-linked homodimer PDGF family member with key roles in development, cell proliferation, cell survival, and angiogenesis. PDGF-BB is expressed by vascular endothelium, megakaryocytes and Leydig cells. PDGF-BB targets pericytes, fibroblasts, monocytes and other cell types (1-3). PDGF induces fibroblast growth and migration and is a chemoattractant for monocytes and granulocytes. Precursor PDGF-BB is cleaved intracellularly to generate a form that contains a carboxy-terminal stretch that serves to retain PDGF-BB in the extracellular matrix. In a second cleavage event, the carboxy-terminal stretch is removed extracellularly to generate mature PDGF-BB. PDGF-BB binds to PDGFR¦Â and induces receptor dimerization. Signaling is through the PI3K/Akt, JNK, and PLC¦Ã pathways. PDGF-BB may have a role in some cancer types.
Synonyms c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV
Reference Data
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.