ALDH2 Rabbit Polyclonal Antibody

CAT#: TA327010

Rabbit anti-ALDH2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of Rat liver cell and Mouse lung cell using ALDH2 antibody.

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  Immunohistochemistry of paraffin-embedded mouse esophagus using ALDH2 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human lung cancer using ALDH2 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human stomach cancer using ALDH2 antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of A549 cell using ALDH2 antibody.

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Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ALDH2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: aldehyde dehydrogenase 2 family (mitochondrial)
• Database Link:
  NP_000681
  Entrez Gene 11669 MouseEntrez Gene 29539 RatEntrez Gene 217 Human
  UniProt ID P05091
• Background: Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.
• Synonyms: ALDH-E2; ALDHI; ALDM

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arginine and proline metabolism, Ascorbate and aldarate metabolism, beta-Alanine metabolism, Butanoate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Glycolysis / Gluconeogenesis, Histidine metabolism, Limonene and pinene degradation, Lysine degradation, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism, Tryptophan metabolism, Valine, leucine and isoleucine degradation