AKR7A2 Rabbit Polyclonal Antibody

CAT#: TA327011

AKR7A2 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using AKR7A2 antibody.

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  Immunohistochemistry of paraffin-embedded mouse heart using AKR7A2 antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded human kidney cancer using AKR7A2 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human AKR7A2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 40 kDa
• Gene Name: aldo-keto reductase family 7, member A2
• Database Link:
  NP_003680
  Entrez Gene 171445 RatEntrez Gene 8574 Human
  UniProt ID O43488
• Background: The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]
• Synonyms: AFAR; AFAR1; AFB1-AR1; AKR7

Reference Data

• Protein Families: Druggable Genome