CARD4 (NOD1) Rabbit Polyclonal Antibody

CAT#: TA327025

Rabbit anti-NOD1 Polyclonal Antibody

Product Images

Western blot analysis of Mouse bladder cell lysate using NOD1 antibody.

• 

  Immunohistochemistry of paraffin-embedded human kidney using NOD1 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded human liver using NOD1 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded human rectal cancer using NOD1 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human NOD1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nucleotide binding oligomerization domain containing 1
• Database Link:
  NP_006083
  Entrez Gene 107607 MouseEntrez Gene 500133 RatEntrez Gene 10392 Human
  UniProt ID Q9Y239
• Background: Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-terminal leucine-rich repeats (LRR). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-¦ÊB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-¦ÊB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.
• Synonyms: CARD4; CLR7.1; NLRC1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway