Tyrosinase (TYR) Rabbit Polyclonal Antibody

CAT#: TA327028

TYR Rabbit Polyclonal Antibody

Product Images

Western blot analysis of HepG2 cell lysate using TYR antibody.

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  Immunohistochemistry of paraffin-embedded human stomach cancer using TYR antibody at dilution of 1:100 (200x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human TYR
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tyrosinase
• Database Link:
  NP_000363
  Entrez Gene 22173 MouseEntrez Gene 308800 RatEntrez Gene 7299 Human
  UniProt ID P14679
• Background: The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3 half of this gene. [provided by RefSeq, Oct 2008]
• Synonyms: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism