Protein C (PROC) Rabbit Polyclonal Antibody

CAT#: TA327046

Rabbit anti-PROC Polyclonal Antibody

Product Images

Western blot analysis of extracts of ES-2 cell lines, using PROC antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PROC
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: protein C, inactivator of coagulation factors Va and VIIIa
• Database Link:
  NP_000303
  Entrez Gene 19123 MouseEntrez Gene 25268 RatEntrez Gene 5624 Human
  UniProt ID P04070
• Background: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
• Synonyms: APC; PC; PROC1; THPH3; THPH4

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades