Carbonic Anhydrase II (CA2) Rabbit Polyclonal Antibody

CAT#: TA327047

CA2 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CA2 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CA2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 29 kDa
• Gene Name: carbonic anhydrase 2
• Database Link:
  NP_000058
  Entrez Gene 760 Human
  UniProt ID P00918
• Background: Carbonic anhydrases (CA) are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes (a, β, and ?) that evolved independently and have no significant homology in sequence and overall folding. All functional CA catalyze the reversible hydration of CO2 into HCO3- and H+ and contain a zinc atom in the active sites essential for catalysis. There are many isoforms of CA in mammals and they all belong to the a class . CA2 is a cytosolic member of the a class. It is the most widely distributed isoform among the mammalian CAs . Defects in CA2 are associated with osteopetrosis and renal tubular acidosis.Elevated expression of CA2 is observed in patients with Alzheimer’s disease and the developing brains of Down syndrome patients . CA2 is also overexpressed in Gastrointestinal Stromal Tumors (GISTs) and is considered a useful marker for diagnosis Recently, CA2 was reported to facilitate transporter activity of the monocarboxylate transporter isoform 1 and 4 (MCT1/4) independent of its own catalytic activity
• Synonyms: CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Nitrogen metabolism