Glucose 6 Phosphate Dehydrogenase (G6PD) Rabbit Polyclonal Antibody

CAT#: TA327067

Rabbit anti-G6PD Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using G6PD antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human G6PD
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glucose-6-phosphate dehydrogenase
• Database Link:
  NP_000393
  Entrez Gene 24377 RatEntrez Gene 2539 Human
  UniProt ID P11413
• Background: Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first and rate-limiting step of the pentose phosphate pathway . The NADPH generated from this reaction is essential to protect cells from oxidative stress . Recent studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway . In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation.
• Synonyms: G6PD1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways, Pentose phosphate pathway