beta 2 Microglobulin (B2M) Rabbit Polyclonal Antibody

CAT#: TA327075

Rabbit anti-B2M Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using B2M antibody.

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  Immunohistochemistry of paraffin-embedded human stomach cancer using B2M antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded mouse heart using B2M antibody at dilution of 1:200 (200x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human B2M
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: beta-2-microglobulin
• Database Link:
  NP_004039
  Entrez Gene 12010 MouseEntrez Gene 24223 RatEntrez Gene 567 Human
  UniProt ID P61769
• Background: β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex,β2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In additon,β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy.
• Synonyms: IMD43

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Antigen processing and presentation