Antithrombin III (SERPINC1) Rabbit Polyclonal Antibody

CAT#: TA327084

Rabbit anti-SERPINC1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using SERPINC1 antibody.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB,1:100 - 1:500
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Mouse, Rat, Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58kDa
• Gene Name: serpin family C member 1
• Database Link:
  NP_000479
  Entrez Gene 11905 MouseEntrez Gene 304917 RatEntrez Gene 462 Human
  UniProt ID P01008
• Background: The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
• Synonyms: AT3; AT3D; ATIII; THPH7

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades