SPARC Rabbit Polyclonal Antibody

CAT#: TA327102

SPARC Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Other products for "SPARC"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 1:500 - 1:2000;IHC 1:50 - 1:200
Reactivities Human, Mouse, Rat P
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human SPARC
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 35 kDa
Gene Name secreted protein acidic and cysteine rich
Background SPARC (secreted protein acidic and rich in cysteine), also known as osteonectin and BM40, is a secreted matricellular glycoprotein that belongs to a group of functionally related glycoproteins that includes tenascins C and X, thrombospondins 1 and 2, and osteopontin. Members in this class of glycoproteins are involved in tissue renewal, tissue remodeling, and embryonic development and work by exerting counter-adhesive and antiproliferative effects that lead to changes in cell shape, disruption of cell adhesion, and inhibition of the cell cycle. SPARC is expressed at high levels in bone tissue but is widely distributed in many other tissues and cell types, and is known to be associated with tissues undergoing morphogenesis, angiogenesis, mineralization, and other pathological responses to injury and tumorigenesis. SPARC has also been linked with obesity and diabetes.
Synonyms BM-40; OI17; ON
Reference Data
Protein Families Druggable Genome

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