CTNND1 Rabbit Polyclonal Antibody

CAT#: TA327119

CTNND1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CTNND1 antibody.

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  Immunofluorescence analysis of U2OS cell using CTNND1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB 1:500 - 1:2000, IHC 1:50- 1:200, ICC 1:50- 1:200, IF 1:50- 1:200, IP 1:50- 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CTNND1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: catenin delta 1
• Database Link:
  NP_001078927
  Entrez Gene 12388 MouseEntrez Gene 311163 RatEntrez Gene 1500 Human
  UniProt ID O60716
• Background: Catenin d-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function . Catenin d-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion . Catenin d-1 has both positive and negative effects on cadherin-mediated adhesion . Actin dynamics are also regulated by catenin d-1, which modulates RhoA, Rac, and cdc42 proteins . Analogous to β-catenin, catenin d-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin d-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin d-1 may function as a tumor suppressor . Phosphorylation of Tyr904 on Catenin-d-1 was identified at Cell Signaling Technology (CST) using PhosphoScan®, a CST's LC-MS/MS platform for phosphorylation site discovery .
• Synonyms: CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Leukocyte transendothelial migration