IL7 Rabbit Polyclonal Antibody

CAT#: TA327124

IL7 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using IL7 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human IL7
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 7
• Database Link:
  NP_000871
  Entrez Gene 16196 MouseEntrez Gene 25647 RatEntrez Gene 3574 Human
  UniProt ID P13232
• Background: IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis . Stromal and epithelial cells within the bone marrow and thymus produce IL-7 (1). The primary targets of IL-7 are T cells, B cells, and dendritic cells . IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7/IL-7R signaling . While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear . In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of naïve and memory aβ T cells, as well as ?d T cells . The IL-7 receptor is a heterodimer of the common ? chain, ?c, and the IL-7-specific IL-7Ra . IL-7 activates PI3K/Akt, Jak1/2, and Stat1, 3, and 5 .
• Synonyms: IL-7

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway