CD46 Rabbit Polyclonal Antibody

CAT#: TA327125

CD46 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CD46 antibody.

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  Immunohistochemistry of paraffin-embedded human kidney using CD46 antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat lung using CD46 antibody at dilution of 1:200 (200x lens).

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  Immunofluorescence analysis of HepG2 cell using CD46 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Rat, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CD46
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD46 molecule
• Database Link:
  NP_758860
  Entrez Gene 29333 RatEntrez Gene 4179 Human
  UniProt ID P15529
• Background: CD46 is a type I membrane protein and a regulatory part of the complement system. This protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, CD46 can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, this protein may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is found in a cluster on chromosome 1q32 with other proteins that are structural components of the complement system.1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.
• Synonyms: AHUS2; MCP; MIC10; TLX; TRA2.10

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades