XRCC4 Rabbit Polyclonal Antibody

CAT#: TA327137

XRCC4 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using XRCC4 antibody.

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  Immunohistochemistry of paraffin-embedded rat pancreas using XRCC4 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human B cell lymphoma using XRCC4 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded human stomach cancer using XRCC4 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human XRCC4
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 4
• Database Link:
  NP_003392
  Entrez Gene 108138 MouseEntrez Gene 309995 RatEntrez Gene 7518 Human
  UniProt ID Q13426
• Background: The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]
• Synonyms: SSMED

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Non-homologous end-joining