Annexin V (ANXA5) Rabbit Polyclonal Antibody

CAT#: TA327155

Rabbit anti-ANXA5 Polyclonal Antibody

Product Images

Western blot analysis of extracts of extracts of HeLa cell lines, using ANXA5 antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ANXA5
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: annexin A5
• Database Link:
  NP_001145
  Entrez Gene 11747 MouseEntrez Gene 308 Human
  UniProt ID P08758
• Background: Annexin V, also known as PAP-1 or Lipocortin V, is a ~30 kDa protein that binds to phospholipids in a calcium-dependent manner. All annexins contain a putative PKC binding site, but only annexin V has been identified as an inhibitor of this pathway. It may also signal, by direct interaction with VEGFR2 receptor, in the regulation of vascular endothelial cell proliferation. Annexin V preferentially binds phosphatidylserine, in competition with prothrombin, leading to inhibition of blood coagulation at sites of injury preceding contact between lipid components and coagulation factors that initiate thrombosis . The ability of Annexin V to bind specifically and robustly to phosphatidylserine makes it an attractive reagent in detecting apoptotic cells. Annexin V is inducible by glucocorticoids and can be phosphorylated by tyrosine and serine/threonine kinases. It is thought to block production of mediators of inflammation, such as prostaglandins and leukotrienes by inhibiting the release of arachidonic acid from membranes by phospholipase A2.
• Synonyms: ANX5; ENX2; HEL-S-7; PP4; RPRGL3