ALDH1A1 Rabbit Polyclonal Antibody

CAT#: TA327181

Rabbit anti-ALDH1A1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ALDH1A1 antibody.

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  Immunohistochemistry of paraffin-embedded human stomach cancer using ALDH1A1 antibody at dilution of 1:200 (200x lens).

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  Immunofluorescence analysis of A549 cell using ALDH1A1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000, IHC 1:50- 1:200, IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ALDH1A1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: aldehyde dehydrogenase 1 family member A1
• Database Link:
  NP_000680
  Entrez Gene 11668 MouseEntrez Gene 24188 RatEntrez Gene 216 Human
  UniProt ID P00352
• Background: The aldehyde dehydrogenase family is a large group of enzymes that oxidize aldehydes formed through metabolic processes to their carboxylic acids. ALDH1A1 is a liver cytosolic isoform of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism along with alcohol dehydrogenase. ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism, converting retinol to retinoic acid. Recent studies suggest that control of retinoid signaling through ALDH1A1 may influence hematopoietic stem cell differentiation. There has been recent interest in ALDH1 isoforms as predictive biomarkers in disease. Several studies have suggested that ALDH1A1 is a potential marker for cancer stem cells and chemoresistance in several tumor types, such as melanoma, lung cancer, glioblastoma.
• Synonyms: ALDC; ALDH-E1; ALDH1; ALDH11; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Metabolic pathways, Retinol metabolism