Ikaros (IKZF1) Rabbit Polyclonal Antibody

CAT#: TA327199

IKZF1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using IKZF1 antibody.

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  Immunofluorescence analysis of U2OS cell using IKZF1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ChIP, ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human IKZF1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: IKAROS family zinc finger 1
• Database Link:
  NP_006051
  Entrez Gene 22778 MouseEntrez Gene 305501 RatEntrez Gene 10320 Human
  UniProt ID Q13422
• Background: Ikaros family proteins, characterized by the presence of an N-terminal zinc finger DNA-binding domain and a C-terminal dimerization domain, belong to the Kruppel transcription factor superfamily. The Ikaros family includes Ikaros, Aiolos, Helios, and possibly EOS and Pegasus. They can form homodimers and heterodimers with other members of the Ikaros family. Due to differential splicing, multiple isoforms can be generated and some behave in a dominant negative manner upon dimerization.Ikaros, also known as Ikaros family zinc finger protein 1 (IKZF1) and Lymphoid transcription factor 1 (LYF-1), is expressed abundantly in blood cells. Genetic studies in mice demonstrate that Ikaros is important for the normal development of B, T, natural killer, and dendritic cells, and that it functions as a tumor suppressor. Research studies have shown that imbalanced expression of different Ikaros isoforms, as well as deletions of Ikaros are associated with hematologic malignancies in humans.
• Synonyms: Hs.54452; IK1; IKAROS; LyF-1; LYF1; PPP1R92; PRO0758; ZNFN1A1

Reference Data

• Protein Families: Druggable Genome, Transcription Factors