DNA Ligase I (LIG1) Rabbit Polyclonal Antibody

CAT#: TA327202

LIG1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using LIG1 antibody.

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  Immunohistochemistry of paraffin-embedded human breast cancer using LIG1 antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of MCF7 cell using LIG1 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200;IF 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human LIG1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DNA ligase 1
• Database Link:
  NP_000225
  Entrez Gene 16881 MouseEntrez Gene 3978 Human
  UniProt ID P18858
• Background: LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq, Jul 2008]
• Synonyms: MGC117397; MGC130025

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair