Amphiregulin (AREG) Rabbit Polyclonal Antibody

CAT#: TA327203

Rabbit anti-AREG Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using AREG antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human AREG
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: amphiregulin
• Database Link:
  NP_001648
  Entrez Gene 11839 MouseEntrez Gene 374 Human
  UniProt ID P15514
• Background: Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs.
• Synonyms: AR; AREGB; CRDGF; SDGF

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ErbB signaling pathway