BMPR1B Rabbit Polyclonal Antibody

CAT#: TA327227

BMPR1B Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of mouse brain cell lines, using BMPR1B antibody.

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  Immunohistochemistry of paraffin-embedded rat kidney using BMPR1B antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat Intestine using BMPR1B antibody at dilution of 1:200 (400x lens).

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  Immunofluorescence analysis of MCF7 cell using BMPR1B antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human BMPR1B
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57 kDa
• Gene Name: bone morphogenetic protein receptor type 1B
• Database Link:
  NP_001194
  Entrez Gene 12167 MouseEntrez Gene 658 Human
  UniProt ID O00238
• Background: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
• Synonyms: ALK-6; ALK6; AMDD; BDA1D; BDA2; CDw293

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway