ADH5 Rabbit Polyclonal Antibody

CAT#: TA327239

Rabbit anti-ADH5 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ADH5 antibody.

• 

  Immunohistochemistry of paraffin-embedded human rectal cancer using ADH5 antibody at dilution of 1:200 (400x lens).

• 

  Immunohistochemistry of paraffin-embedded rat testis using ADH5 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: ELISA, ICC/IF, IF, IHC, WB
• Recommended Dilution: WB,1:500 - 1:2000
  IF/ICC,1:50 - 1:200
  ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 40kDa
• Gene Name: alcohol dehydrogenase 5 (class III), chi polypeptide
• Database Link:
  NP_000662
  Entrez Gene 11532 MouseEntrez Gene 100145871 RatEntrez Gene 128 Human
  UniProt ID P11766
• Background: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
• Synonyms: ADH-3; ADHX; FALDH; FDH; GSH-FDH; GSNOR; HEL-S-60p

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Methane metabolism, Retinol metabolism, Tyrosine metabolism