PDE1B Rabbit Polyclonal Antibody

CAT#: TA327270

Rabbit anti-PDE1B Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PDE1B antibody.

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  Immunohistochemistry of paraffin-embedded human kidney cancer using PDE1B antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded human lung cancer using PDE1B antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PDE1B
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phosphodiesterase 1B
• Database Link:
  NP_000915
  Entrez Gene 18574 MouseEntrez Gene 29691 RatEntrez Gene 5153 Human
  UniProt ID Q01064
• Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Synonyms: PDE1B1; PDES1B

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism