Aurora A (AURKA) Rabbit Polyclonal Antibody

CAT#: TA327283

AURKA Rabbit Polyclonal Antibody


USD 275.00

3 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications ICC/IF, WB
Recommended Dilution WB: 1:500-1:2000
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide of human AURKA
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name aurora kinase A
Background Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.
Synonyms AIK; ARK1; AURA; BTAK; PPP1R47; STK6; STK7; STK15
Reference Data
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways Oocyte meiosis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.